Publikationen (Auswahl):

2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023



Ragavan VN, Nair PC, Jarzebska N, Angom RS, Ruta L, Bianconi E, Grottelli S, Tararova ND, Ryazanskiy D, Lentz SR, Tommasi S, Martens-Lobenhoffer J, Suzuki-Yamamoto T, Kimoto M, Rubets E, Chau S, Chen Y, Hu X, Bernhardt N, Spieth PM, Weiss N, Bornstein SR, Mukhopadhyay D, Bode-Böger SM, Maas R, Wang Y, Macchiarulo A, Mangoni AA, Cellini B, Rodionov RN.
A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase.
Nature Communications 2023; 14: 3392.

Agarwal B, Cañizares RB, Saliba F, Ballester MP, Tomescu DR, Martin D, Stadlbauer V, Wright G, Sheikh M, Morgan C, Alzola C, Lavin P, Green D, Kumar R, Sacleux SC, Schilcher G, Koball S, Tudor A, Minten J, Domenech G, Aragones JJ, Oettl K, Paar M, Waterstradt K, Bode-Böger SM, Ibáñez-Samaniego L, Gander A, Ramos C, Chivu A, Stange J, Lamprecht G, Sanchez M, Mookerjee RP, Davenport A, Davies N, Pavesi M, Andreola F, Albillos A, Cordingley J, Schmidt H, Carbonell-Asins JA, Arroyo V, Fernandez J, Mitzner S, Jalan R.
Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure.
J Hepatol 2023;79: 79-92

König C, Martens-Lobenhoffer J, Czorlich P,Westphal M, Bode-Böger SM, Kluge S, Grensemann J.
Cerebrospinal fluid penetration of fosfomycin in patients with ventriculitis: an observational study.
Ann Clin Microbiol Antimicrob 2023 Apr 24; 22(1): 29.

Kozlova AA, Rubets E, Vareltzoglou MR, Jarzebska N, Ragavan VN, Chen Y, Martens-Lobenhoffer J, Bode-Böger SM, Gainetdinov RR, Rodionov RN, Bernhardt N.
Knock-out of the critical nitric oxide synthase regulator DDAH1 in mice impacts amphetamine sensitivity and dopamine metabolism.
J Neural Transm 2023: Feb 16.


Martens-Lobenhoffer J, Böger CR, Kielstein J, Bode-Böger SM.
Simultaneous quantification of nirmatrelvir and ritonavir by LC-MS/MS in patients treated for COVID-19.
J Chromatogr B 2022; 1212: 123510.

Rodionov RN, Jarzebska N, Burdin D, Todorov V, Martens-Lobenhoffer J, Hofmann A, Kolouschek A, Cordasic N, Jacobi J, Rubets E, Morawietz H, O'Sullivan JF, Markov AG, Bornstein SR, Hilgers K, Maas R, Pfluecke C, Chen Y, Bode-Böger SM, Hugo CPM, Hohenstein B, Weiss N.
Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling.
Sci Rep 2022; 12(1): 9381.

Brandt S, Fischer A, Kreutze C, Hempel D, Gorny X, Scurt FG, Şalaru DL, Bartsch P, Bernhardt A, Bode-Böger SM, Girndt M, Fiedler R, Isermann B, Lindquist JA, Mertens PR.
Midkine release during hemodialysis is predictive of hypervolemia and associates with excess (cardiovascular) mortality in patients with end-stage renal disease: a prospective study.
Int Urol Nephrol 2022; 54: 2407-2420.

Martens-Lobenhoffer J, Angermair S, Bode-Böger SM.
Quantification of ceftazidime/avibactam in human plasma and dried blood spots: Implications on stability and sample transport.
J Chromatogr B 2022; 1193: 123164

Martens-Lobenhoffer J,Tomaras S, Feist E, Bode-Böger SM.
Quantification of the janus kinase 1 inhibitor upadacitinib in human plasma by LC-MS/MS.
J Chromatogr B 2022; 1188:

Martens-Lobenhoffer J, Bode-Böger SM.
Mixed experiences with commercial calibrators and controls for COVID-19 drugs.
J Appl Lab Med 2022; 7:617-619.


Kopaliani I, Jarzebska N, Billoff S, Kolouschek A, Martens-Lobenhoffer J, Bornstein SR, Bode-Böger SM, Ragavan VN, Weiss N, Mangoni AA, Deussen A, Rodionov RN.
Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II-induced cardiac hypertrophy and vascular remodelling.
Am. J. Physiol. Heart Circ. Physiol. 2021; 321(5): H825-H838

Gerecke lKV, Schmid T JJ, Hafer C, Eden G, Bode-Böger SM, Martens-Lobenhoffer J, Welte T, Kielstein JT.
Fosfomycin single- and multiple-dose pharmacokinetics in patients undergoing prolonged intermittent renal replacement therapy.
J Antimicrob Chemother; 2021: Sep 29; 

Schmidt JJ, Bode-Böger SM, Martens-Lobenhoffer J, Hoeper MM, Kielstein JT.
Pharmacokinetics of Remdesivir and GS-441524 during PIRRT and Seraph 100 Therapy. (Research Letter)
CJASN. 2021; 16: 1256-1257.

Rodionov RN, Beyer-Westendorf J, Bode-Böger SM, Eggebrecht L, Konstantinides S, Martens-Lobenhoffer J, Nagler M, Prochaska J, Wild P.
Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism.
Sci Rep. 2021; 11: 9569.

Seffer MT, Martens-Lobenhoffer J, Schmidt JJ, Eden G, Bode-Böger SM, Kielstein JT.
Clearance of chloroquine and hydroxychloroquine by the Seraph® 100 Microbind® Affinity blood filter - approved for the treatment of COVID-19 patients.
Ther Apher Dial. 2021; 25: 237-5241


Stautemas J, Jarzebska N, Shan ZX, Blancquaert L, Everaert I, de Jager S, De Baere S, Hautekiet A, Volkaert A, Lefevere FBD, Martens-Lobenhoffer J, Bode-Böger SM, Kim CK, Leiper J, Weiss N, Croubels S, Rodionov RN, Derave W.
The role of alanine glyoxylate transaminase-2 (agxt2) in β-alanine and carnosine metabolism of healthy mice and humans.
Eur J Appl Physiol. 2020; 120: 2749-2759.

Putzer AS, Worthmann H, Grosse GM, Goetz F, Martens-Lobenhoffer J, Dirks M, Kielstein JT, Lichtinghagen R, Budde U, Bode-Böger SM, Weissenborn K, Schuppner R.
ADAMTS13 activity is associated with early neurological improvement in acute ischemic stroke patients treated with intravenous thrombolysis.
J Thromb Thrombolysis. 2020; 49: 67-74.

Martens-Lobenhoffer J, Hinderhofer M, Tröger U, Bode-Böger SM.
Stability of ceftolozane in human plasma and dried blood spots: implications for transport and storage.
J Pharmacol Toxicol Methods 2020; 103: 106692.


Rodionov RN, Jarzebska N, Schneider A, Rexin A, Sradnick J, Brilloff S, Martens-Lobenhoffer J, Bode-Böger SM, Todorov V, Hugo C, Weiss N, Hohenstein B.
ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus.
Atheroscler Suppl. 2019 Dec;40:100-105Sep 3.

Ziegler NL, Sieweke JT, Biber S, Gabriel MM, Schuppner R, Worthmann H, Martens-Lobenhoffer J, Lichtinghagen R, Bode-Böger SM, Bavendiek U, Weissenborn K, Grosse GM.
Markers of endothelial pathology to support detection of atrial fibrillation in embolic stroke of undetermined source.
Sci Rep. 2019 Dec 19;9(1):19424.

Jarzebska N, Mangoni AA, Martens-Lobenhoffer J, Bode-Böger SM, Rodionov RN.
The Second Life of Methylarginines as Cardiovascular Targets.
Int J Mol Sci. 2019 Sep 17;20(18). pii: E4592.

Rodionov RN, Begmatov H, Jarzebska N, Patel K, Mills MT, Ghani Z, Khakshour D, Tamboli P, Patel MN, Abdalla M, Assaf M, Bornstein SR, Millan JL, Bode-Böger SM, Martens-Lobenhoffer J, Weiss N, Savinova OV.
Homoarginine supplementation prevents left ventricular dilatation and preserves systolic function in a model of coronary artery disease.
J Am Heart Assoc. 2019 Jul 16;8(14): e012486.

Martens-Lobenhoffer J, Monastyrski D, Tröger U, Bode-Böger SM.
Stability of meropenem in plasma versus dried blood spots (DBS).
Journal of Pharmaceutical and Biomedical Analysis 2019; 170: 279-284.

Grosse GM, Biber S, Sieweke JT, Martens-Lobenhoffer J, Gabriel MM, Putzer AS, Hasse I, van Gemmeren T, Schuppner R, Worthmann H, Lichtinghagen R, Bode-Böger SM, Bavendiek U, Weissenborn K.
Plasma Dimethylarginine Levels and Carotid Intima-Media Thickness are related to Atrial Fibrillation in Patients with Embolic Stroke.
Int J Mol Sci. 2019 Feb 9;20(3).

Schmidt JJ, Strunk AK, David S, Bode-Böger SM, Martens-Lobenhoffer J, Knitsch W, Scherneck S, Welte T, Kielstein JT.
Single- and multiple-dose pharmacokinetics and total removal of colistin in critically ill patients with acute kidney injury undergoing prolonged intermittent renal replacement therapy.
J Antimicrob Chemother 2019; 74: 997-1002.


Martens-Lobenhoffer J, Emrich IE, Zawada AM, Fliser D, Wagenpfeil S, Heine GH, Bode-Böger SM.
L-Homoarginine and its AGXT2-metabolite GOCA in chronic kidney disease as markers for clinical status and prognosis.
Amino Acids 2018; 50: 1347-1356.

Erdbrügger U, Kielstein JT, Westman K, Ma JZ, Xin W, Bode-Böger SM, Segelmark M, Rasmussen N, De Groot K.
Higher levels of SDMA and not ADMA are associated with poorer survival of trial patients with systemic ANCA-associated vasculitis.
Eur J Rheumatol 2018; 5: 153-159.

Mertens A, Barche D, Scheinpflug L, Scholz FG, Vielhaber S, Scherlach C, Tröger U, Geginat G, Färber J, Arens C.
Rhinocerebrale Mucormykose.
Laryngorhinootologie 2018; 97: 550-554.

Schuppner R, Dirks M, Grosse GM, Böckmann M, Goetz F, Pasedag T, Bode-Böger SM, Martens-Lobenhoffer J, Budde U, Lanfermann H, Lichtinghagen R, Weissenborn K, Worthmann H.
ADAMTS-13 activity predicts outcome in acute ischaemic stroke patients undergoing endovascular treatment.
Thromb Haemost 2018;118: 758-767.

Emrich IE, Zawada AM, Martens-Lobenhoffer J, Fliser D, Wagenpfeil S, Heine GH, Bode-Böger SM.
Symmetric dimethylarginine (SDMA) outperforms asymmetric dimethylarginine (ADMA) and other methylarginines as predictor of renal and cardiovascular outcome in non-dialysis chronic kidney disease.
Clin Res Cardiol 2018; 107: 201-213.


Worthmann H, Li N, Martens-Lobenhoffer J, Dirks M, Schuppner R, Lichtinghagen R, Kielstein JT, Raab P, Lanfermann H, Bode-Böger SM, Weissenborn K.
Dimethylarginines in patients with intracerebral hemorrhage: association with outcome, hematoma enlargement, and edema.
J Neuroinflammation 2017; 14: 247-255.

Rodionov RN, Heinrich A, Brilloff S, Jarzebska N, Martens-Lobenhoffer J, Bode-Böger SM, Todorov V, Hugo CP, Weiss N, Hohenstein B.
ADMA reduction does not protect mice with streptozotocin-induced diabetes mellitus from development of diabetic nephropathy.
Atherosclerosis Supplements 2017; 30: 319-325.

Martens-Lobenhoffer J, Bode-Böger SM.
Quantification of meropenem in human plasma by HILIC – tandem mass spectrometry.
J Chromatogr B 2017; 1046: 13-17.

Martens-Lobenhoffer J, Bode-Böger SM.
Separation of the structural isomers of monomethylarginine in human plasma by 2-D-HPLC and MS-MS detection.
Chromatographia 2017; 80: 45-51.


Bode-Böger SM.
Polypharmazie bei Dialysepatienten.
Dialyse aktuell 2016; 20 (Suppl. 1): S3.

Burdin DV, Kolobov AA, Brocker C, Soshnev AA, Samusik N, Demyanov AV, Brilloff S, Jarzebska N, Martens-Lobenhoffer J, Mieth M, Maas R, Bornstein SR, Bode-Böger SM, Gonzalez F, Weiss N, Rodionov RN. D
iabetes-linked transcription factor HNF4
α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanineglyoxylate aminotransferase 2.
Sci Rep 2016; 6: 35503-35515

Rodionov RN, Oppici E, Martens-Lobenhoffer J, Jarzebska N, Brilloff S, Burdin D, Demyanov A, Kolouschek A, Leiper J, Maas R, Cellini B, Weiss N, Bode-Böger SM.
A Novel Pathway for Metabolism of the Cardiovascular Risk Factor Homoarginine by alanine: glyoxylate aminotransferase 2.
Sci Rep 2016; 6: 35277-35288.

Schmidt JJ, Bode-Böger SM, Wilhelmi M, Omar M, Martens-Lobenhoffer J, Welte T, Kielstein JT.
Pharmacokinetics and total removal of fosfomycin in two patients undergoing intermittent haemodialysis and extended dialysis: prescription needs to avoid under-dosing.
J Antimicrob Chemother 2016; 71: 2673-2674.

Schmidt JJ, Ramazan L, Bockemeyer C, Günter HH, Martens-Lobenhoffer J, Ganzenmüller T, Bode-Böger SM, Kielstein JT.
Acute interstitial nephritis due to flecainide therapy in the 38th week of pregnancy.
BMC Nephrology 2016, 17: 28.

Rodionov RN, Martens-Lobenhoffer J, Brilloff S, Burdin DV, Jarzebska N, Demyanov AV, Hohenstein B, Weiss N, Bode-Böger SM.
Acetylation of asymmetric and symmetric dimethylarginine: an undercharacterized pathway of metabolism of endogenous
Nephrol Dial Transplant 2016; 31: 57-63.

Martens-Lobenhoffer J, Bode-Böger SM, Clement B.
First detection and quantification of Ndelta-monomethylarginine, a structural isomer of NG-monomethylarginine, in humans using MS3.
Analytical Biochemistry 2016; 493: 14-20.

Bode-Böger SM, Tröger U.
Therapeutisches Drug Monitoring (TDM) bei Intensivpatienten mit mulitresistenter Keimbesiedlung.
In: Kluge S, Markewitz A, Jorch G, Putensen C. Quintel M, Sybrecht GW (Hrsg.). DIVI Jahrbuch 2015/2016, Fortbildung und Wissenschaft in der interdisziplinären Intensivmedizin und Notfallmedizin, Schwerpunkt “Hygiene in der Intensivmedizin". Medizinisch Wissenschaftliche Verlagsgesellschaft, Berlin, 2016, S. 29-37.


Bode-Böger SM, Tröger U.
Therapeutisches Drug Monitoring von Reserveantibiotika.
Intensivmed.up2date 2015; 11: 293-308.

Kielstein H, Suntharalingam M, Perthel R, Song R, Schneider SM, Martens-Lobenhoffer J, Jäger K, Bode-Böger SM, Kielstein JT.
Role of the endogenous nitric oxide inhibitor asymmetric dimethylarginine (ADMA) and brain-derived neurotrophic factor (BDNF) in depression and behavioural changes: clinical and preclinical data in chronic kidney disease.
Nephrol Dial Transplant 2015; 30: 1699-1705.

Martens-Lobenhoffer J, Bode-Böger SM.
A validated method for the quantification of fosfomycin in human plasma by
liquid chromatography-tandem mass spectrometry.
J Chromatogr B 2015; 990: 164-168.

Martens-Lobenhoffer J, Bode-Böger SM.
Amino acid N-acetylation: Metabolic elimination of symmetric dimethylarginine as symmetric Nα-acetyldimethylarginine, determined in human plasma and urine by LC-MS/MS.
J Chromatogr B 2015; 975: 59-64.

Tafelski S, Nachtigall I, Troeger U, Deja M, Krannich A, Günzel K, Spies C, for the ABx
Study Group.
Observational clinical study on the effects of different dosing regimens on vancomycin target levels in critically ill patients: Continuous versus intermittent application.
J Infect Public Health 2015; 8: 355-363.


Rodionov RN, Martens-Lobenhoffer J, Brilloff S, Hohenstein B, Jarzebska N, Jabs N, Kittel A, Maas R, Weiss N, Bode-Böger SM.
Role of alanine:glyoxylate aminotransferase 2 in metabolism of asymmetric dimethylarginine in the settings of asymmetric dimethylarginine overload and bilateral nephrectomy.
Nephrol Dial Transplant 2014; 29: 2035-2042.

Bode-Böger SM.
Optimierung der Antiinfektivatherapie mittels therapeutischen Drug-Monitorings.
Der Nephrologe 2014; 9: 457-464.

Krajewski J, Bode-Böger SM, Tröger U, Martens-Lobenhoffer J, Mulrooney T, Mittelstädt H, Russlies M, Kirchner R, Knobloch JKM.
Successful treatment of extensively drug-resistant Pseudomonas aeruginosa osteomyelitis using a colistin- and tobramycin-impregnated PMMA spacer.
Int J Antimicrob Agents 2014; 44: 363-366.

Strunk AK, Schmidt JJ, Baroke E, Bode-Böger SM, Martens-Lobenhoffer J, Welte T, Kielstein JT.
Single-and multiple-dose pharmacokinetics and total removal of colistin in a patient with acute kidney injury undergoing extended daily dialysis.
J Antimicrob Chemother. 2014; 69: 2008-2010.

Martens-Lobenhoffer J, Bode-Böger SM.
Mass spectrometric quantification of L-arginine and its pathway related substances in biofluids: the road to maturity.
J Chromatogr B 2014; 964: 89-102.

Schepers E, Speer T, Bode-Böger SM, Fliser D, Kielstein JT.
Dimethylarginines ADMA and SDMA: The real water-soluble small toxins?
Semin Nephrol 2014; 34: 97-105.

Martens-Lobenhoffer J, Rodionov RN, Bode-Böger SM.
Determination of asymmetric N alpha-acetyldimethylarginine in humans: a phase II metabolite of asymmetric dimethylarginine.
Anal Biochem 2014; 452: 25-30.

Lukasz A, Hoffmeister B, Graf B, Wölk B, Noeckler K, Bode-Böger SM, Hadem J, Pischke S, Kielstein JT.
Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis.
PLoS ONE 2014; 9(1): e87490.

Scalera F, Bode-Böger SM.
Asymmetric dimethylarginine accelerates cellular senescence.
In: Hayat MA (Hrsg.). Tumor Dormancy, Quiescence, and Senescence, Volume 2: Aging, Cancer, and Noncancer Pathologies. Springer Science+Business Media Dordrecht 2014, S. 3-16.


Martens-Lobenhoffer J, Surdacki A, Bode-Böger SM.
Fast and precise quantification of L-homoarginine in human plasma by HILIC-isotope dilution-MS-MS.
Chromatographia 2013; 76: 1755-1759.

Tutarel O, Röntgen P, Bode-Böger SM, Martens-Lobenhoffer J, Westhoff-Bleck M, Diller GP, Bauersachs J, Kielstein JT.
Symmetrical dimethylarginine is superior to NT-proBNP for detecting systemic ventricular dysfunction in adults after atrial repair for transposition of the great arteries.
Int J Cardiol 2013; 168: 4415-4416.

Jaźwińska-Kozuba A, Martens-Lobenhoffer J, Kruszelnicka O, Rycaj J, Chyrchel B, Surdacki A, Bode-Böger SM.
Opposite associations of plasma homoarginine and ornithine with arginine in healthy children and adolescents.
Int J Mol Sci 2013; 14: 21819-21832.

Bode-Böger SM, Schopp B, Tröger U, Martens-Lobenhoffer J, Kalousis K, Mailänder P.
Intravenous colistin in a patient with serious burns and borderline syndrome: The benefits of therapeutic drug monitoring.
Int J Antimicrob Agents 2013; 42: 357-360.

Tamás P, Bódis J, Sulyok E, Kovács GL, Hantosi E, Molnár G, Martens-Lobenhoffer J, Bode-Böger SM.
L-arginine metabolism in early-onset and late-onset pre-eclamptic pregnancies.
Scand J Clin Lab Invest 2013; 73: 436-43.

Worthmann H, Martens-Lobenhoffer J, Joumaah M, Li N, Lichtinghagen R, Hecker H, Kielstein JT, Ehrenreich H, Bode-Böger SM, Weissenborn K.
Asymmetric dimethylarginine in response to recombinant tissue-type plasminogen activator and erythropoietin in acute stroke.
Stroke 2013; 44: 2128-2133.

Veldink H, Faulhaber-Walter R, Park JK, Martens-Lobenhoffer J, Bode-Böger SM, Schuett H, Haghikia A, Hilfiker-Kleiner D, Kielstein JT.
Effects of chronic SDMA infusion on glomerular filtration rate, blood pressure, myocardial function and renal histology in C57BL6/J mice.
Nephrol Dial Transplant 2013; 28: 1434-1439.

Beutel G, Perthel R, Suntharalingam M, Bode-Böger SM, Martens-Lobenhoffer J, Kielstein JT, Kielsteinn H.
Effect of chronic elevated asymmetric dimethylarginine (ADMA) levels on granulopoiesis.
Ann Hematol 2013; 92: 505-508.

Kittel A, Maas R, König J, Mieth M, Weiss N, Jarzebska N, Hohenstein B, Martens-Lobenhoffer J, Bode-Böger SM, Rodionov RN.
In vivo evidence that Agxt2 can regulate plasma levels of dimethylarginines in mice.
Biochem Biophys Res Commun 2013; 430: 84-9.


Padberg JS, Meurs M, Kielstein JT, Martens-Lobenhoffer J, Bode-Böger SM, Zijlstra JG, Kovesdy CP, Kümpers P.
Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia.
Exp Transl Stroke Med 2012; 4: 24.

Chen S, Martens-Lobenhoffer J, Weissenborn K, Kielstein JT, Lichtinghagen R, Deb M, Li N, Tryc AB, Goldbecker A, Dong Q, Bode-Böger SM, Worthmann H.
Association of dimethylarginines and mediators of inflammation after acute ischemic stroke.
J Neuroinflammation 2012; 9: 251.

Martens-Lobenhoffer J, Rodionov RN, Bode-Böger SM.
Probing AGXT2 enzyme activity in mouse tissue by applying stable isotope-labeled asymmetric dimethyl arginine as substrate.
J Mass Spectrom 2012; 47: 1594-1600.

Jaźwińska-Kozuba A, Martens-Lobenhoffer J, Surdacki A, Kruszelnicka O, Rycaj J, Godula-Stuglik U, Bode-Böger SM.
Associations between Endogenous Dimethylarginines and Renal Function in Healthy Children and Adolescents.
Int J Mol Sci 2012; 13: 15464-15474.

Six I, Maizel J, Barreto FC, Rangrez AY, Dupont S, Slama M, Tribouilloy C, Choukroun G, Maziere JC, Bode-Böger SM, Kielsltein JT, Drüeke TB, Massy ZA.
Effects of phosphate on vascular function under normal conditions and influence of the uraemic state.
Cardiovasc Res 2012; 96: 130-139.

Vida G, Sulyok E, Ertl T, Martens-Lobenhoffer J, Bode-Böger SM.
Birth by cesarean section is associated with elevated neonatal plasma levels of dimethylarginines.
Pediatrics International 2012; 54: 476-479.

Tröger U, Drust A, Martens-Lobenhoffer J, Tanev I, Braun-Dullaeus RC, Bode-Böger SM.
Decreased meropenem levels in intensive care unit patients with augmented renal clearance: benefit of therapeutic drug monitoring.
International Journal of Antimicrobial Agents 2012; 40: 370-372.

Martens-Lobenhoffer J, Bode-Böger SM.
Quantification of L-arginine, asymmetric dimethylarginine and symmetric dimethylarginine in human plasma: a step improvement in precision by stable isotope dilution mass spectrometry.
J Chromatogr B 2012; 904: 140-143.

Drust A, Luchtmann M, Firsching R, Tröger U, Martens-Lobenhoffer J, Bode-Böger SM.
Recurrent seizures in a levetiracetam-treated patient after subarachnoid hemorrhage: a matter of enhanced renal function?
Epilepsy & Behavior 2012; 23: 394-395.

Kielstein JT, Suntharalingam M, Perthel R, Rong S, Martens-Lobenhoffer J, Jäger K, Bode-Böger SM, Nave H.
Asymmetric dimethylarginine may mediate increased heat pain threshold in experimental chronic kidney disease.
Nephrol Dial Transplant 2012; 27: 899-902.

Bukowska A, Lendeckel U, Bode-Böger SM, Götte A.
Physiologic and pathopyhsiologic role of calpain: implications for the occurrence of atrial fibrillation.
Cardiovasc Ther 2012; 30: e115 – e127.

Tutarel O, Denecke A, Bode-Böger SM, Martens-Lobenhoffer J, Lovric S, Bauersachs J, Schieffer B, Westhoff-Bleck M, Kielstein JT.
Asymmetrical dimethylarginine – more sensitive than NT-proBNP to diagnose heart failure in adults with congenital heart disease.
PLoS ONE 2012; 7: Issue 3, e33795, 1-6.

Götte A, Hammwöhner M, Bukowska A, Scalera F, Martens-Lobenhoffer J, Dobrev D, Ravens U, Weinert S, Medunjanin S, Lendeckel U, Bode-Böger SM.
The impact of rapid atrial pacing on ADMA and endothelial NOS.
Int J Cardiol 2012; 154: 141-6.

Scherbakov N, Sandek A, Martens-Lobenhoffer J, Kung T, Turhan G, Liman T, Ebinger M, v. Haehling S, Bode-Böger SM, Endres M, Doehner W.
Endothelial dysfunction of the peripheral vascular bed in the acute phase after ischemic stroke.
Cerebrovasc Dis 2012; 33: 37-46.


Kielstein JT, Veldink H, Martens-Lobenhoffer J, Haller H, Perthel R, Lovric S, Lichtinghagen R, Kliem V, Bode-Böger SM.
Unilateral nephrectomy causes an abrupt increase in inflammatory mediators and a simultaneous decrease in plasma ADMA: a study in living kidney donors.
Am J Physiol Renal Physiol 2011; 301: F1042–F1046.

Worthmann H, Chen S, Martens-Lobenhoffer J, Li N, Deb M, Tryc AB, Goldbecker A, Dong Q, Kielstein JT, Bode-Böger SM, Weissenborn K.
High plasma dimethylarginine levels are associated with adverse clinical outcome after stroke.
J Atheroscler Thromb 2011; 18: 753-761.

Lehmann HI, Götte A, Martens-Lobenhoffer J, Hammwöhner M, Röhl F-W, Bukowska A, Ghanem A, Klein HU, Bode-Böger SM.
Asymmetric dimethylarginine predicts appropriate implantable cardioverter–defibrillator intervention in patients with left ventricular dysfunction.
Europace 2011; 13: 1428-1435.

Martens-Lobenhoffer J, Rodionov RN, Drust A, Bode-Böger SM.
Detection and quantification of a-keto-d-(NG,NG-dimethylguanidino)valeric acid: a metabolite of asymmetric dimethylarginine.
Analytical Biochemistry 2011; 419: 234-240.

Bugnicourt JM, da Silveira C, Bengrine A, Godefroy O, Baumbach GL, Sevestre H, Bode-Böger SM, Kielstein JT, Massy ZA, Chillon JM.
Chronic renal failure alters endothelial function in cerebral circulation in mice.
Am J Physiol Heart Circ Physiol 2011; 301: H1143-H1152.

Martens-Lobenhoffer J, Rupprecht V, Bode-Böger SM.
Determination of micafungin and anidulafungin in human plasma: UV- or mass spectrometric quantification?
J Chrom B 2011; 879: 2051-2056.

Cziráki A, Ajtay Z, Németh A, Lenkey Z, Sulyok E, Szabados S, Alotti N, Martens-Lobenhoffer J, Szabó C, Bode-Böger SM.
Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine.
Coron Artery Dis 2011; 22: 245-52.

Kielstein JT, Veldink H, Martens-Lobenhoffer J, Haller H, Burg M, Lorenzen JM, Lichtinghagen R, Bode-Böger SM, Kliem V.
SDMA is an early marker of change in GFR after living-related kidney donation.
Nephrol Dial Transplant 2011; 26: 324-328.

Reiche I, Westphal S, Martens-Lobenhoffer J, Tröger U, Luley C, Bode-Böger SM.
Pharmacokinetics and dose recommendations of Niaspan® in chronic kidney disease and dialysis patients.
Nephrol Dial Transplant 2011; 26: 276-282.

Tutarel O, Denecke A, Bode-Böger SM, Martens-Lobenhoffer J, Schieffer B, Westhoff-Bleck M, Kielstein JT.
Symmetrical Dimethylarginine Outperforms CKD-EPI and MDRD-Derived eGFR for the Assessment of Renal Function in Patients with Adult Congenital Heart Disease.
Kidney Blood Press Res 2011; 34: 41-45.


Bódis J, Várnagy Á, Sulyok E, Kovács GL, Martens-Lobenhoffer J, Bode-Böger SM.
Negative association of L-arginine methylation products with oocyte numbers.
Hum Reprod 2010; 25: 3095-3100.

v. Haehling S, Bode-Böger SM, Martens-Lobenhoffer J, Rauchhaus M, Schefold JC, Genth-Zotz S, Karhausen T, Cicoira M, Anker SD, Doehner W.
Elevated levels of asymmetric dimethylarginine in chronic heart failure: a pathophysiologic link between oxygen radical load and impaired vasodilator capacity and the therapeutic effect of allopurinol.
Clin Pharmacol Ther 2010; 88: 506-512.

Götte A, Wolfram O, Jentsch-Ullrich K, Martens-Lobenhoffer J, Scalera F, Lendeckel U, Bode-Böger SM.
The effects of G-CSF-induced mobilization of progenitor cells are limited by ADMA.
Int J Cardiol 2010; 143: 264-270.

Tröger U, Reiche I, Jepsen MS, Huth C, Bode-Böger SM.
Esomeprazole-induced rhabdomyolysis in a patient with heart failure.
Intensive Care Med 2010; 36: 1278-1279.

David S, Kümpers P, Lukasz A, Fliser D, Martens-Lobenhoffer J, Bode-Böger SM, Kliem V, Haller H, Kielstein JT.
Circulating angiopoietin-2 levels increase with progress of chronic kidney disease.
Nephrol Dial Transplant 2010; 25: 2571-2576.

Rifai K, Bode-Böger SM, Martens-Lobenhoffer J, Ernst T, Kretschmer U, Hafer C, Fliser D, Manns MP, Kielstein JT.
Removal of asymmetric dimethylarginine during artificial liver support using fractionated plasma separation and adsorption.
Scand J Gastroenterol 2010; 45: 1110-1115.

Reiche I, Tröger U, Martens-Lobenhoffer J, Kandulski A, Neumann H, Malfertheiner P, Bode-Böger SM.
Omeprazole-induced cough in a patient with gastroesophageal reflux disease.
Eur J Gastroenterol Hepatol 2010; 22: 880-882.

Bahte SK, Bertram A, Burkhardt O, Martens-Lobenhoffer J, Goedecke V, Bode-Böger SM, Hiss M, Kielstein JT.
Therapeutic serum concentrations of daptomycin after intraperitoneal administration in a patient with peritoneal dialysis-associated peritonitis.
J Antimicrob Chemother 2010; 65: 1312-1314.

Rifai K, Bode-Böger SM, Martens-Lobenhoffer J, Ernst T, Kretschmer U, Hafer C, Fliser D, Manns MP, Kielstein JT.
Removal of asymmetric dimethylarginine during artificial liver support using fractionated plasma separation and adsorption.
Scand J Gastroenterol 2010; online 1-6

Pletz MW, Bloos F, Burkhardt O, Brunkhorst FM, Bode-Böger SM, Martens-Lobenhoffer J, Greer MW, Stass H, Welte T.
Pharmacokinetics of moxifloxacin in patients with severe sepsis or septic shock.
Intensive Care Med 2010; 36: 979-983.

Kielstein JT, Engbers C, Bode-Böger SM, Martens-Lobenhoffer J, Haller H, Joukhadar C, Traunmüller F, Knitsch W, Hafer C, Burkhardt O.
Dosing of daptomycin in intensive care unit patients with acute kidney injury undergoing extended dialysis – a pharmacokinetic study.
Nephrol Dial Transplant 2010; 25: 1537-1541.

Schmidt K, Martens-Lobenhoffer J, Meinitzer A, Graier WF, Torres CM, Venema RC, Mayer B.
Activation of endothelial nitric oxide synthase by the pro-apoptotic drug embelin: Striking discrepancy between nitric oxide-mediated cyclic GMP accumulation and L-citrulline formation.
Nitric Oxide 2010; 22: 281-289.

Lorenzen J, Krämer R, Kliem V, Bode-Böger SM, Veldink H, Haller H, Fliser D, Kielstein JT.
Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease.
Eur J Clin Invest 2010; 40: 294-300.

Ajtay Z, Németh A, Sulyok E, Cziráki A, Szabados S, Martens-Lobenhoffer J, Awiszus F, Szabó C, Bode-Böger SM.
Effect of stent implementation on plasma levels of asymmetric dimethylarginine in patients with or without ST-segment elevation acute myocardial infarction.
Int J Mol Med 2010; 25: 617-624.

Henken S, Bohling J, Martens-Lobenhoffer J, Paton JC, Ogunniyi AD, Briles DE, Salisbury VC, Wedekind D, Bode-Böger SM, Welsh T, Bange FC, Welte T, Maus UA.
Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmunary infections with streptococcus pneumoniae.
Antimicrob Agents Chemother 2010; 54: 707-717.

Scalera F, Bode-Böger SM.
Nitric oxide – asymmetric dimethylarginine system in endothelial cell senescence.
In: Ignarro L (Hrsg.). Nitric Oxide: Biology and Pathobiology. 2. Edition. Elsevier Academic Press Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney Tokio, 2010, S. 483-511.

Martens-Lobenhoffer J, Dautz C, Bode-Böger SM.
Improved method for the determination of cyclic guanosine monophosphate (cGMP) in human plasma by LC-MS/MS..
J Chromatogr B 2010; 878: 487-491.


Scalera F, Fulge B, Martens-Lobenhoffer J, Heimburg A, Bode-Böger SM.
Red wine decreases asymmetric dimethylarginine via SIRT1 induction in human endothelial cells.
Biochem Biophys Res Comm 2009; 390: 703 – 709.

Martens-Lobenhoffer J, Schwedhelm E, Tsikas D.
Quantification of arginine and its mono- and dimethylated analogs NMMA, ADMA and SDMA in biological fluids by LC-MS/MS: is LC superfluous?
J Chromatogr B 2009; 877: 3261-3266.

Kielstein J, Burkhardt O, Bode-Böger SM.
Dose matters: dose of antibiotics in the critically ill patient depends on the dose of renal replacement therapy. (Letter to the Editor)
Crit Care Med 2009; 37: 2491.

Martens-Lobenhoffer J, Becker A, Freude H, Bode-Böger SM.
Identification and quantification of the atypical metabolite ornithine-lactam in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
J Chromatogr B 2009; 877: 2284-2289.

Scalera F, Closs EI, Flick E, Martens-Lobenhoffer J, Boissel JP, Lendeckel U, Heimburg A, Bode-Böger SM.
Paradoxical effect of L-arginine: acceleration of endothelial cell senescence.
BBRC 2009; 386: 650-655.

Reiche I, Tröger U, Postel SC, Wolf R, Bode-Böger SM.
Valproic acid-induced myopathy in a patient with schizoaffective disorder. (Letter to the Editor)
J Clin Psychopharmacol 2009; 29: 402-403.

Kielstein JT, Hesse, G, Bahr MJ, Tsikas D, Terkamp C, Martens-Lobenhoffer J, Manns MP, Haller H, Panning B, Bode-Böger SM, Gebel M.
Procedure-related pulmonary hypertension in patients with hepatocellular carcinoma undergoing percutaneous ethanol injection – role of ethanol, hemolysis, asymmetric dimethylarginine, and the nitric oxide system.
Crit Care Med 2009; 37: 1483-1485.

Ajtay Z, Scalera F, Cziráki A, Horváth I, Papp L, Sulyok E, Szabo C, Martens-Lobenhoffer J, Awiszus F, Bode-Böger SM.
Stent placement in patients with coronary heart disease decreases plasma levels of the endogenous nitric oxide synthase inhibitor ADMA.
Int J Mol Med 2009; 23: 651-657.

Surdacki A, Martens-Lobenhoffer J, Wloch A, Gluszko P, Rakowski T, Dubiel JS, Bode-Böger SM.
Plasma asymmetric dimethylarginine is related to anticitrullinated protein antibodies in rheumatoid arthritis of short duration.
Metabolism Clinical and Experimental 2009; 58: 316-318.

Vida G, Sulyok E, Lakatos O, Ertl T, Martens-Lobenhoffer J, Bode-Böger SM.
Plasma levels of asymmetric dimethylarginine in premature neonates: its possible involvement in developmental programming of chronic diseases.
Acta Paediatrica 2009; 98: 437-441.

Gödecke VA, Clajus C, Burkhardt O, Martens-Lobenhoffer J, Bode-Böger SM, Kielstein JT, Hiss M.
Pharmacokinetics and dialysate levels of daptomycin given intravenously in a peritoneal dialysis patient.
Scand J Infect Dis 2009; 41: 155-157.


Surdacki A, Martens-Lobenhoffer J, Brzozowska-Czarnek A, Rakowski T, Galicka-Latala D, Wieczorek-Surdacka E, Mielecki W, Urbanik A, Dudek D, Dubiel JS, Bode-Böger SM.
Excessive epicaridial fat volume is not associated with elevated plasma asymmetrical dimethyl-L-arginine in optimally treated patients after myocardial infarction.
Kardiodiabetologia 2008; 3: Nr. 1 – 2, 1 – 4.

Tröger U, Postel SC, Bode-Böger SM.
Aktuelle und zukünftige Pharmakotherapie obstruktiver Atemwegserkrankungen aus klinisch-pharmakologischer Sicht.
Atemw.-Lungenkrkh 2008; 34: 450-453.

Martens-Lobenhoffer J, Kielstein JT, Oye C, Bode-Böger SM.
Validated high performance liquid chromatography-UV detection method for the determination of daptomycin in human plasma.
J Chromatogr B 2008; 875: 546-550.

Scalera F, Martens-Lobenhoffer J, Bukowska A, Lendeckel U, Täger M, Bode-Böger SM.
Effect of telmisartan on nitric oxide–asymmetrical dimethylarginine system: role of angiotensin II type 1 receptor and peroxisome proliferator activated receptor gamma signaling during endothelial aging.
Hypertension 2008; 51: 696-703.

Csiky B, Sulyok E, Lakatos O, Wittmann I, Martens-Lobenhoffer J, Bode-Böger SM.
Response of asymmetric dimethylarginine to hemodialysis-associated hypotension in end-stage renal disease patients.
Nephron Clin Pract 2008; 108: c127-c134.

Treiber G, Wex T, Schleyer E, Tröger U, Hosius C, Malfertheiner P.
Imatinib for hepatocellular cancer – Focus on pharmacokinetic/pharmacodynamic modelling and liver function.
Cancer Letters 2008; 260: 146-154.


Martens-Lobenhoffer J, Reiche I, Tröger U, Mönkemüller K, Malfertheiner P, Bode-Böger SM.
Enantioselective quantification of omeprazole and its main metabolites in human serum by chiral HPLC–atmospheric pressure photoionization tandem mass spectrometry.
J Chromatogr B 2007; 857: 301-307.

Martens-Lobenhoffer J, Postel S, Tröger U, Bode-Böger SM.
Determination of ornithine in human plasma by hydrophilic interaction chromatography – tandem mass spectrometry.
J Chromatogr B 2007; 855: 271-275.

Bode-Böger SM, Scalera F, Ignarro L.J.
The L-arginine paradox: importance of the L-arginine/asymmetrical dimethylarginine ratio.
Pharmacol Ther 2007; 114: 295-306.

Martens-Lobenhoffer J, Sulyok E, Czeiter E, Büki A, Kohl J, Firsching R, Tröger U, Bode-Böger SM.
Determination of cerebrospinal fluid concentrations of arginine and dimethylarginines in patients with subarachnoid haemorrhage.
J Neurosci Methods 2007; 164: 155-160.

Martens-Lobenhoffer J, Bode-Böger SM.
Chromatographic-mass spectrometric methods for the quantification of L-arginine and its methylated metabolites in biological fluids.
J Chromatogr B 2007; 851: 30-41.

Walter S, Kuchenbecker J, Banditt P, Bode-Böger SM, Behrens-Baumann W.
Concentration of moxifloxacin in serum and human aqueous humor following a single 400 mg oral dose.
JCRS 2007; 33: 553-555.

Vida G, Sulyok E, Ertl T, Martens-Lobenhoffer J, Bode-Böger SM.
Plasma asymmetric dimethylarginine concentration during the perinatal period.
Neonatology 2007; 92: 8-13.

Surdacki A, Martens-Lobenhoffer J, Wloch A, Marewicz E, Rakowski T, Wieczorek-Surdacka E, Dubiel JS, Pryjma J, Bode-Böger SM.
Elevated plasma asymmetric dimethyl-L-arginine levels are linked to endothelial progenitor cell depletion and carotid atherosclerosis in rheumatoid arthritis.
Arthritis Rheum 2007; 56: 809-819.

Surdacki A, Stochmal E, Szurkowska M, Bode-Böger SM, Martens-Lobenhoffer J, Stochmal A, Klecha A, Kawecka-Jaszcz K, Dubiel JS, Huszno B, Szybinski Z.
Nontraditional atherosclerotic risk factors and extent of coronary atherosclerosis in patients with combined impaired fasting glucose and impaired glucose tolerance.
Metabolism 2007; 56: 77-86.

Wieczorek-Surdacka E, Surdacki A, Bode-Böger SM, Schubert B, Sulowicz W.
Elevated plasma asymmetric dimethyl-L-arginine in a patient with Gordon syndrome.
Nephrol Dial Transplant 2007; 22: 268-271.


Bode-Böger SM, Tröger U.
Therapeutisches Drug Monitoring – Indikationen und Interpretation.
In: Frölich JC, Kirch W (Hrsg.). Praktische Arzneitherapie. 4. aktualisierte und überarbeitete Auflage. Springer-Verlag Berlin, Heidelberg, 2006

Tröger U, Bode-Böger SM.
Stellenwert von Neuraminidase-Hemmern in der Prophylaxe und Therapie der Influenza.
Dtsch Ärztebl 2006; 103: A 3486 - 3492.

Kielstein J, Donnerstag F, Gasper S, Menne J, Fliser D, Kielstein A, Martens-Lobenhoffer J, Scalera F, Bode-Böger SM, Cooke J.
Response to letter by Tsuda – Asymmetric dimethylarginine and cerebrovascular disorders in humans.
Stroke 2006; 37: 2871.

Kalousová M, Kielstein JT, Hodková M, Zima T, Dusilová-Sulková S, Martens-Lobenhoffer J, Bode-Böger SM.
No benefit of hemodiafiltration over hemodialysis in lowering elevated levels of asymmetric dimethylarginine in ESRD patients.
Blood Purif 2006; 24: 439-444.

Kielstein JT, Salpeter SR, Bode-Böger SM, Cooke JP, Fliser D.
Symmetric dimethylarginine (SDMA) as endogenous marker of renal function – a meta-analysis.
Nephrol Dial Transplant 2006; 21: 2446-2451.

Kielstein JT, Donnerstag F, Gasper S, Menne J, Kielstein A, Martens-Lobenhoffer J, Scalera F, Cooke JP, Fliser D, Bode-Böger SM.
ADMA increases arterial stiffness and decreases cerebral blood flow in humans.
Stroke 2006; 37: 2024-2029.

Götte A, Hammwöhner M, Dierkes J, Lachmuth J, Frölich JC, Klein H, Bode-Böger SM.
Aortic thrombus and pulmonary embolism in a patient with hyperhomocysteinemia.
Nat Clin Pract Cardiovasc Med 2006; 3: 396 – 399.

Postel SC, Bode-Böger SM.
Zu Risiken und Nebenwirkungen fragen Sie Ihren Arzt oder Apotheker.
Ärzteblatt Sachsen-Anhalt 2006; 17: Heft 6, S. 16 – 20, 41 – 42.

Scalera F, Martens-Lobenhoffer J, Täger M, Bukowska A, Lendeckel U, Bode-Böger SM.
Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging.
Biochem Biophys Res Comm 2006; 345: 1075 – 1082.

Bode-Böger SM.
L-Arginin – präventive Wirkung bei Arteriosklerose?
Perfusion 2006; 19: 92 – 98.
Journal Pharmakol u Ther 2006; 5: 155 – 162.

Menne J, Park JK, Agrawal R, Lindschau C, Kielstein JT, Kirsch T, Marx A, Muller D, Bahlmann FH, Meier M, Bode-Böger SM, Haller H, Fliser D.
Cellular and molecular mechanisms of tissue protection by lipophilic calcium channel blockers.
FASEB J 2006; 20: E150 – E159.

Bode-Böger SM, Scalera F, Kielstein JT, Martens-Lobenhoffer J, Breithardt G, Fobker M, Reinecke H.
Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease.
J Am Soc Nephrol 2006; 17: 1128-1134.

Westphal S, Taneva E, Kästner S, Martens-Lobenhoffer J, Bode-Böger S, Kropf S, Dierkes J, Luley C.
Endothelial dysfunction induced by postprandial lipemia is neutralized by addition of proteins to the fatty meal.
Atherosclerosis 2006, 185: 313-319.

Meyer F, Gebauer T, Grote R, Martens-Lobenhoffer J, Ridwelski K, Lippert H.
Results of regional chemotherapy using the aortic stop-flow technique in advanced pancreatic carcinoma.
Surg Today 2006; 36: 155-161.

Martens-Lobenhoffer J, Bode-Böger SM.
Fast and Efficient Determination of Arginine, Symmetric Dimethylarginine, and Asymmetric Dimethylarginine in Biological Fluids by Hydrophilic-Interaction Liquid Chromatography–Electrospray Tandem Mass Spectrometry.
Clinical Chemistry 2006; 52: 488-493.

Westphal S, Borucki K, Luley C, Martens-Lobenhoffer J, Bode-Böger SM.
Treatment with niacin lowers ADMA.
Atherosclerosis 2006; 184: 448-450.

Kielstein J, Czock D, Schöpcke T, Hafer C, Bode-Böger SM, Kuse E, Keller F, Fliser D.
Pharmacokinetics and total elimination of meropenem and vancomycin in intensive care unit patients undergoing extended daily dialysis.
Crit Care Med 2006; 34: 51-56.

Bode-Böger SM.
Effect of L-arginine supplementation on NO production in man.
Eur J Clin Pharmacol 2006; 62: 91 – 99.

Martens-Lobenhoffer J, Bode-Böger SM.
Measurement of asymmetric dimethylarginine (ADMA) in human plasma: from liquid chromatography estimation to liquid chromatography-mass spectrometry quantification.
Eur J Clin Pharmacol 2006; 62: 61 – 68.


Meyer F, Ridwelski K, Gebauer T, Grote R, Martens-Lobenhoffer J, Lippert H.
Pharmacokinetics of the antineoplastic drug mitomycin C in regional chemotherapy using the aortic stop flow technique in advanced pancreatic carcinoma.
Chemotherapy 2005; 51 (1): 1 - 8.

Martens-Lobenhoffer J, Westphal S, Awiszus F, Bode-Böger SM, Luley C.
Determination of asymmetric dimethylarginine: liquid chromatography-mass spectrometry or ELISA?
Clinical Chemistry 2005; 51: 2188-2189.

Tröger U, Lins H, Scherrmann JM, Wallesch CW, Bode-Böger SM.
Tetraparesis associated with colchicine is probably due to inhibition by verapamil of the P-glycoprotein efflux pump in the blood-brain barrier.
BMJ 2005; 331: 613.

Bode-Böger SM, Kojda G.
Organic nitrates in cardiovascular disease.
Cell Mol Biol 2005; 51: 307-320.

Bode-Böger SM, Scalera F, Martens-Lobenhoffer J.
Asymmetric dimethylarginine (ADMA) accelerates cell senescence.
Vasc Med 2005; 10: S65-71.

Bode-Böger SM, Martens-Lobenhoffer J, Täger M, Schröder H, Scalera F.
Aspirin reduces endothelial cell senescence.
Biochem Biophys Res Comm 2005; 334: 1226-1232.

Fliser D, Kronenberg F, Kielstein JT, Morath C, Bode-Böger SM, Haller H, Ritz E.
Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study.
J Am Soc Nephrol 2005; 16: 2456-2461.

Kielstein J, Bode-Böger SM (equally contributed), Hesse G, Martens-Lobenhoffer J, Takacs A, Fliser D, Hoeper MM.
Asymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension.
Arterioscler Thromb Vasc Biol 2005; 25: 1414-1418.

Lorenz P, Zeh M, Martens-Lobenhoffer J, Schmidt H,Wolf G, Horn TFW.
Natural and newly synthesized hydroxy-1-aryl-isochromans: A class of potential antioxidants and radical scavengers.
Free Radical Research 2005; 39: 535-545.

Martens-Lobenhoffer J, Bode-Böger SM.
Determination of levetiracetam in human plasma with minimal sample pretreatment.
J Chromatogr B 2005; 819: 197-200.

Postel SC, Bode-Böger SM.
Erfassung von Aspekten der Arzneimittelsicherheit in der Apotheke – Fakt oder Fiktion?
Apothekenmagazin 2005; 23 (4): 72-78.

Scalera F, Kielstein J, Martens-Lobenhoffer J, Postel S, Täger M, Bode-Böger SM.
Erythropoietin increases asymmetric dimethylarginine in endothelial cells – role of dimethylarginine dimethylaminohydrolase.
J Am Soc Nephrol 2005; 16: 892-898.

Bode-Böger SM.
Einfluss von L-Arginin auf die Arterioskleroseentwicklung: Was ist therapeutisch gesichert?
Dtsch Med Wochenschr 2005; 130: 593-598.


Scalera F, Borlak J, Beckmann B, Martens-Lobenhoffer J, Thum T, Täger M, Bode-Böger SM.
Endogenous NO-synthesis inhibitor asymmetric dimethyl L-arginine (ADMA) accelerates endothelial cell senescence.
Arterioscler Thromb Vasc Biol 2004; 24: 1816-1822.

Martens-Lobenhoffer J, Krug O, Bode-Böger SM.
Determination of arginine and asymmetric dimethylöarginine (ADMA) in human plasma by liquid chromatography/mass spectrometry with the isotope dilution technique.
J Mass Spectrom 2004; 39: 1287-1294.

Kielstein JT, Impraim B, Simmel S, Bode-Böger SM, Tsikas D, Frölich JC, Hoeper MM, Haller H, Fliser D.
Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans.
Circulation 2004; 109: 172-177.

Kielstein JT, Simmel S, Bode-Böger SM, Roth HJ, Schmidt-Gayk H, Haller H, Fliser D.
Subpressor dose asymmetric dimethylarginine modulates renal function in humans through nitric oxide synthase inhibition.
Kidney Blood Press Res 2004; 27: 143-147.

Kielstein JT, Böger RH, Bode-Böger SM, Martens-Lobenhoffer J, Lonnemann G, Frölich JC, Haller H, Fliser D.
Low dialysance of asymmetric dimethylarginine (ADMA) – in vivo and in vitro evidence of significant protein binding.
Clinical Nephrology 2004; 62: 295-300.

Sydow K, Hornig B, Arakawa N, Bode-Böger SM,Tsikas D, Münzel T, Böger RH.
Endothelial dysfunction in patients with peripheral arterial disease and chronic hyperhomocysteinemia: potential role of ADMA.
Vasc Med 2004; 9: 93-101.

Böger RH, Tsikas D, Bode-Böger SM, Phivthong-ngam L, Schwedhelm E, Frölich JC.
Hypercholesterolemia impairs basal nitric oxide synthase turnover rate: a study investigating the conversion of L-[guanidino-15N2]-arginine to 15N-labeled nitrate by gas chromatography-mass spectrometry.
Nitric Oxide 2004; 11: 1-8, online.

Dierkes J, Westphal S, Martens-Lobenhoffer J, Luley C, Bode-Böger SM.
Fenofibrate increases the L-arginine: ADMA ratio by increase of L-arginine concentration but has no effect on ADMA concentration.
Atherosclerosis 2004; 173: 239-244.


Martens-Lobenhoffer J, Bode-Böger SM.
Simultaneous detection of arginine, asymmetric dimethylarginine, symmetric dimethylarginine and citrulline in human plasma and urine applying liquid chromatography-mass spectrometry with very straightforward sample preparation.
J Chromatogr B 2003; 798: 231-239.
Top Cited Article Award 2001 - 2006.

Bode-Böger SM, Muke J, Surdacki A, Brabant G, Böger RH, Frölich JC.
Oral L-arginine improves endothelial function in healthy individuals older than 70 years.
Vasc Med 2003, 8: 77-81.

Sydow K, Schwedhelm E, Arakawa N, Bode-Böger SM, Tsikas D, Hornig B, Frölich JC, Böger RH.
ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.
Cardiovasc Res 2003; 57: 244-252.

Kielstein JT, Bode-Böger SM, Frölich JC, Ritz E, Haller H, Fliser D.
Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects.
Circulation 2003, 107: 1891-1895.

Kielstein JT, Bode-Böger SM, Graf S, Haller H, Fliser D.
Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure.
Eur J Clin Invest 2003, 33: 370-375.

Fliser D, Kielstein JT, Haller H, Bode-Böger SM.
Asymmetric dimethylarginine: a cardiovascular risk factor in renal disease?
Kidney Int 2003; 63 (Suppl. 84): 37-40.

Kielstein JT, Bode-Böger SM, Haller H, Fliser D.
Functional changes in the ageing kidney: is there a role for asymmetric dimethylarginine?
Nephrol Dial Transplant 2003; 18: 1245-1248.

Bode-Böger SM, Tröger U.
Therapeutisches Drug Monitoring – Indikationen und Interpretation.
In: Frölich JC, Kirch W (Hrsg.). Praktische Arzneitherapie. 3. aktualisierte und überarbeitete Auflage. Springer-Verlag Berlin, Heidelberg, New York, Hongkong, London, Mailand, Paris, Tokio, 2003

Tröger U, Bode-Böger S.
Arzneistoffinteraktionen mit Protonenpumpen-Inhibitoren.

Dt Ärztebl 2003; 100: A2245.


Kielstein JT, Böger RH, Bode-Böger SM, Frölich JC, Haller H, Ritz E, Fliser D.
Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease.
J Am Soc Nephrol 2002; 13: 170-176.

Tröger U, Bode-Böger SM.
Methotrexate treatment and mortality in rheumatoid arthritis.
Lancet 2002; 360: 1095.

Martens-Lobenhoffer J.
Very sensitive and specific determination of sufentanil in human serum applying liquid chromatography-two stage mass spectrometry.
J Chromatogr B 2002; 769: 227-233.

Martens-Lobenhoffer J, Banditt P.
Clinical Pharmacokinetics of Dorzolamide.
Clin Pharmacokinet 2002;. 41: 197-205.

Tröger U, Stötzel B, Martens-Lobenhoffer J, Gollnick H, Meyer FP.
Severe myalgia from an interaction between treatments with pantoprazole and methotrexate.
BMJ 2002; 321: 1497.

Schwarz N, Banditt P, Gerlach KL, Meyer FP.
Absorption kinetics of paracetamol are not influenced by high anxiety levels in preoperative patients.
Int J Clin Pharmacol 2002; 40: 419-421.

Ulrich S, Läuter J.
Comprehensive survey of the relationship between serum concentration and therapeutic effect of amitriptyline in depression.
Clin Pharmacokinet 2002, 41: 853-876.


Zoccali C, Bode-Böger SM, Mallamaci F, Benedetto FA, Tripepi G, Malatino L, Catalotti A, Bellanuova I, Fermo I, Frölich JC, Böger RH.
Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study.
Lancet 2001; 358: 2113-2117.

Böger RH, Bode-Böger SM.
The clinical pharmacology of L-arginine.
Annu Rev Pharmacol Toxicol 2001; 41: 79-99.

Walker HA, McGing E, Fisher I, Böger RH, Bode-Böger SM, Jackson G, Ritter JM, Chowienczyk PJ.
Endothelium-dependent vasodilation is independent of the plasma L-arginine/ADMA ratio in men with stable angina: lack of effect of oral L-arginine on endothelial function, oxidative stress and exercise performance.
J Am Coll Cardiol 2001; 38(2): 499-505.

Böger RH, Lentz SR, Bode-Böger SM, Knapp HR. Haynes WG.
Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans.
Clin Sci 2001; 100: 161-167.

Kielstein JT, Bode-Böger SM, Frölich JC, Haller H, Böger RH.
Relationship of asymmetric dimethylarginine to dialysis treatment and atherosclerotic disease.
Kidney Int 2001; 59 (Suppl. 78): 9-13.

Martens-Lobenhoffer J, Banditt P.
Sensitive and specific determination of clindamycin in human serum and bone tissue applying liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.
J Chromatogr B 2001; 755: 143-149.

Lössner A, Banditt P, Tröger U.
Rapid and simple method for detection of fenofibric acid in human serum by high-performance liquid chromatography.
Pharmazie 2001; 56: 50-51.

Dierkes J, Westphal S, Kunstmann S, Banditt P, Lössner A, Luley C:
Vitamin supplementation can markedly reduce the homocysteine elevation induced by fenofibrate.
Atherosclerosis 2001; 158: 161-164.


Böger RH, Bode-Böger SM.
Asymmetric dimethylarginine, derangements of the endothelial nitric oxide synthase pathway, and cardiovascular diseases.
Semin Thromb Hemost 2000; 26: 539-545.

Böger RH, Bode-Böger SM, Tsao PS, Lin PS, Chan JR, Cooke JP.
An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes.
J Am Coll Cardiol 2000; 36: 2287-95.

Köhler GI, Bode-Böger SM, Busse R, Hoopmann M, Welte T, Böger RH.
Drug-drug interactions in medical patients: effects of in-hospital treatment and relation to multiple drug use.
Int J Clin Pharmacol Ther 2000; 38: 504-513.

Tsikas D, Böger RH, Sandmann J, Bode-Böger SM, Frölich JC.
Hypothesis: Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox.
FEBS Lett 2000; 478: 1-3.

Böger RH, Sydow K, Borlak J, Thum T, Lenzen H, Schubert B, Tsikas D, Bode-Böger SM.
LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine (ADMA) in human endothelial cells. Involvement of S-adenosylmethionine-dependent methyltransferases.
Circ Res 2000; 87: 99-105.

Böger RH, Bode-Böger SM, Sydow K, Heistad DD, Lentz SR.
Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia.
Arterioscler Thromb Vasc Biol 2000; 20: 1557-1564.

Brandes RP, Brandes S, Böger RH, Bode-Böger SM, Mügge A.
L-arginine supplementation in hypercholesterolemic rabbits normalizes leukocyte adhesion to non-endothelial matrix.
Life Sci 2000; 66:1519-24.

Chan JR, Böger RH, Bode-Böger SM, Tangphao O, Tsao PS, Blaschke TF, Cooke JP.
Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans.
Arterioscler Thromb Vasc Biol 2000; 20: 1040-1046.

Böger RH, Bode-Böger SM, Matsuoka H, Miyazaki H, Usui M, Ueda S, Okuda S, Imaizumi T, Cooke JP.
Is asymmetric dimethylarginine a novel marker of atherosclerosis?
Circulation 2000; 101: E160-E161.

Bode-Böger SM, Böger RH, Kielstein JT, Löffler M, Schäffer J, Frölich JC.
Role of endogenous nitric oxide in circadian blood pressure regulation in healthy humans and in patients with hypertension or atherosclerosis.
J Investig Med 2000; 48: 125-132.

Osterziel KJ, Bode-Böger SM, Strohm O, Ellmer AE, Bit-Avragim N, Hänlein D, Ranke MB, Dietz R, Böger RH.
Role of nitric oxide in the vasodilator effect of recombinant human growth hormone in patients with dilated cardiomyopathy.
Cardiovasc Res 2000; 45: 447-453.

Tröger U, Brandt W, Röse W.
A very early onset of respiratory failure due to phenytoin-associated hypersensitivity syndrome and concomitant glucocorticoid administration.
Intensive Care Med 2000; 26: 258.

Darius J, Banditt P.
Validated method for the therapeutic drug monitoring of flunitrazepam in human serum using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry with an ion trap detector.
J Chromatogr B Biomed Sci Appl 2000; 738: 437-441.

Tröger U, Brandt W, Röse W.
Development of a pulmonary phenytoin-associated hypersensitivity reaction despite concomitant dexamethasone and prednisolone administration.
Int J Clin Pharmacol Ther 2000; 38: 452-456.

Ulrich, S.
Solid-phase microextraction in biomedical analysis.
J Chromatogr A 2000; 902: 167-194.
Top Cited Article Award 2000 - 2004.

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